Cogentech

Pubblicazioni R&D

  1. Clonal cooperation through soluble metabolite exchange facilitates metastatic outgrowth by modulating Allee effect.
    Hershey BJ, Barozzi S, Orsenigo F, Pompei S, Iannelli F, Kamrad S, Matafora V, Pisati F, Calabrese L, Fragale G, Salvadori G, Martini E, Totaro MG, Magni S, Guan R, Parazzoli D, Maiuri P, Bachi A, Patil KR, Cosentino Lagomarsino M, Havas KM.
    Sci Adv. 2023 Sep 15;9(37): eadh4184. doi: 10.1126/sciadv.adh 4184. Epub 2023 Sep 15. PMID: 37713487
  2. De novo germline pathogenic variant in Lynch Syndrome: A rare event or the tip of the iceberg?
    Brignola C, Volorio S, De Vecchi G, Zaffaroni D, Dall'Olio V, Mariette F, Sardella D, Capra F, Signoroni S, Rausa E, Vitellaro M, Pensotti V, Ricci MT.
    Tumori. 2023 Sep 11:3008916231197113. doi: 10.1177/03008916231197113. Online ahead of print. PMID: 37691472
  3. Fasting mimicking diet in mice delays cancer growth and reduces immunotherapy-associated cardiovascular and systemic side effects.
    Cortellino S, Quagliariello V, Delfanti G, Blaževitš O, Chiodoni C, Maurea N, Di Mauro A, Tatangelo F, Pisati F, Shmahala A, Lazzeri S, Spagnolo V, Visco E, Tripodo C, Casorati G, Dellabona P, Longo VD.
    Nat Commun. 2023 Sep 8;14(1):5529. doi: 10.1038/s41467-023-41066-3. PMID: 37684243
  4. Exploring the Role of Hsp60 in Alzheimer's Disease and Type 2 Diabetes: Suggestion for Common Drug Targeting.
    Zimbone S, Di Rosa MC, Chiechio S, Giuffrida ML.
    Int J Mol Sci. 2023 Aug 5;24(15):12456. doi: 10.3390/ijms241512456. PMID: 37569831
  5. Correlation between biological and mechanical properties of extracellular matrix from colorectal peritoneal metastases in human tissues.
    Lorenc E, Varinelli L, Chighizola M, Brich S, Pisati F, Guaglio M, Baratti D, Deraco M, Gariboldi M, Podestà A.
    Sci Rep. 2023 Jul 27;13(1):12175. doi: 10.1038/s41598-023-38763-w. PMID: 37500685.
  6. NF1 Gene Inactivation Acts as Tumor Driver in RET/RAS Negative Medullary Thyroid Carcinomas.
    Ciampi R, Ramone T, Romei C, Casalini R, Matrone A, Prete A, Gambale C, Minardi SP, Caparezza G, Pierotti MA, Torregrossa L, Ugolini C, Materazzi G, Elisei R.
    Eur J Endocrinol. 2023 May 22: lvad051. doi: 10.1093/ejendo/lvad051. PMID: 37216402
  7. Counteracting gemcitabine+nab-paclitaxel induced dysbiosis in KRAS wild type and KRASG12D mutated pancreatic cancer in vivo model.
    Panebianco C, Pisati F, Villani A, Andolfo A, Ulaszewska M, Bellini E, Ferro C, Lombardi R, Orsenigo F, Latiano TP, Belmonte B, Tripodo C, Perri F, Pazienza V.
    Cell Death Discov. 2023 Apr 5;9(1):116. doi: 10.1038/s41420-023-01397-y. PMID: 37019893.
  8. SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence.
    Gioia U, Tavella S, Martínez-Orellana P, Cicio G, Colliva A, Ceccon M, Cabrini M, Henriques AC, Fumagalli V, Paldino A, Presot E, Rajasekharan S, Iacomino N, Pisati F, Matti V, Sepe S, Conte MI, Barozzi S, Lavagnino Z, Carletti T, Volpe MC, Cavalcante P, Iannacone M, Rampazzo C, Bussani R, Tripodo C, Zacchigna S, Marcello A, d'Adda di Fagagna F.
    Nat Cell Biol. 2023 Apr;25(4):550-564. doi: 10.1038/s41556-023-01096-x. Epub 2023 Mar 9. PMID: 36894671.
  9. Fumarate induces vesicular release of mtDNA to drive innate immunity.
    Zecchini V, Paupe V, Herranz-Montoya I, Janssen J, Wortel IMN, Morris JL, Ferguson A, Chowdury SR, Segarra-Mondejar M, Costa ASH, Pereira GC, Tronci L, Young T, Nikitopoulou E, Yang M, Bihary D, Caicci F, Nagashima S, Speed A, Bokea K, Baig Z, Samarajiwa S, Tran M, Mitchell T, Johnson M, Prudent J, Frezza C.
    Nature. 2023 Mar;615(7952):499-506. doi: 10.1038/s41586-023-05770-w. Epub 2023 Mar 8. PMID: 36890229.
  1. Targeting the DNA Damage Response Pathways and Replication Stress in Colorectal Cancer.
    Durinikova E, Reilly NM, Buzo K, Mariella E, Chilà R, Lorenzato A, Dias JML, Grasso G, Pisati F, Lamba S, Corti G, Degasperi A, Cancelliere C, Mauri G, Andrei P, Linnebacher M, Marsoni S, Siena S, Sartore-Bianchi A, Nik-Zainal S, Di Nicolantonio F, Bardelli A, Arena S.
    Clin Cancer Res. 2022 Sep 1;28(17):3874-3889. doi: 10.1158/1078-0432.CCR-22-0875. PMID: 35881546; PMCID: PMC9433963.
  2. Single cell-derived spheroids capture the self-renewing subpopulations of metastatic ovarian cancer.
    Velletri T, Villa CE, Cilli D, Barzaghi B, Lo Riso P, Lupia M, Luongo R, López-Tobón A, De Simone M, Bonnal RJP, Marelli L, Piccolo S, Colombo N, Pagani M, Cavallaro U, Minucci S, Testa G.
    Cell Death Differ. 2022 Mar;29(3):614-626. doi: 10.1038/s41418-021-00878-w. Epub 2021 Nov 29. PMID: 34845371; PMCID: PMC8901794.
  3. Cancer-Related Intracellular Signaling Pathways Activated by DOXorubicin/Cyclodextrin-Graphene-Based Nanomaterials.
    Pennisi R, Musarra-Pizzo M, Velletri T, Mazzaglia A, Neri G, Scala A, Piperno A, Sciortino MT.
    Biomolecules. 2022 Jan 1;12(1):63. doi: 10.3390/biom12010063. PMID: 35053211; PMCID: PMC8773469.
  4. Direct cleavage of caspase-8 by herpes simplex virus 1 tegument protein US11.
    Musarra-Pizzo M, Pennisi R, Lombardo D, Velletri T, Sciortino MT.
    Sci Rep. 2022 Jul 19;12(1):12317. doi: 10.1038/s41598-022-15942-9. PMID: 35853963; PMCID: PMC9296525.
  5. Sequencing of SARS-CoV-2 Extracted from Critical Material from Swabs.
    Vacca D, Fiannaca A, Tramuto F, Cancila V, La Paglia L, Mazzucco W, Gulino A, La Rosa M, Maida CM, Morello G, Belmonte B, Casuccio A, Maugeri R, Iacopino G, Balistreri CR, Vitale F, Tripodo C, Urso A.
    Direct RNA Nanopore Life (Basel). 2022 Jan 4;12(1):69. doi: 10.3390/life12010069. PMID: 35054462; PMCID: PMC8778588.
  6. Decellularized extracellular matrix as scaffold for cancer organoid cultures of colorectal peritoneal metastases.
    J Varinelli L, Guaglio M, Brich S, Zanutto S, Belfiore A, Zanardi F, Iannelli F, Oldani A, Costa E, Chighizola M, Lorenc E, Minardi SP, Fortuzzi S, Filugelli M, Garzone G, Pisati F, Vecchi M, Pruneri G, Kusamura S, Baratti D, Cattaneo L, Parazzoli D, Podestà A, Milione M, Deraco M, Pierotti MA, Gariboldi M.
    Mol Cell Biol. 2022 Dec 2:mjac064. doi: 10.1093/jmcb/mjac064. Epub ahead of print. PMID: 36460033.
  7. Exploring the association with disease recurrence of miRNAs predictive of colorectal cancer.
    Zanutto S, Ciniselli CM, Belfiore A, Dall'Olio V, Tizzoni L, Varinelli L, Pierotti MA, Battaglia L, Verderio P, Guaglio M, Gariboldi M.
    Int J Biol Markers. 2022 Mar;37(1):102-109. doi: 10.1177/17246008211064915. Epub 2021 Dec 21. PMID: 34931559.
  8. ERO1 alpha deficiency impairs angiogenesis by increasing N-glycosylation of a proangiogenic VEGFA. Redox
    Varone E, Chernorudskiy A, Cherubini A, Cattaneo A, Bachi A, Fumagalli S, Erol G, Gobbi M, Lenardo MJ, Borgese N, Zito E.
    Biol. 2022 Oct; 56:102455. doi: 10.1016/j.redox.2022.102455. Epub 2022 Aug 27. PMID:36063727; PMCID: PMC9463388.
  9. Case Report: Male Lobular Breast Cancer in Hereditary Cancer Syndromes.
    Carnevali I, Tedaldi G, Pensotti V, Sahnane N, Micello D, Rovera F, Sessa F, Tibiletti MG.
    Front Oncol. 2022 May 24; 12:891426. doi: 10.3389/fonc.2022.891426. PMID: 35686104; PMCID: PMC9171007.
  10. NR1H3 (LXRα) is associated with pro-inflammatory macrophages, predicts survival and suggests potential therapeutic rationales in diffuse large b-cell lymphoma.
    Vegliante MC, Mazzara S, Zaccaria GM, De Summa S, Esposito F, Melle F, Motta G, Sapienza MR, Opinto G, Volpe G, Bucci A, Gargano G, Enjuanes A, Tabanelli V, Fiori S, Minoia C, Clemente F, Negri A, Gulino A, Morello G, Scattone A, Zito AF, Tommasi S, Agostinelli C, Vitolo U, Chiappella A, Barbui AM, Derenzini E, Zinzani PL, Casadei B, Rivas-Delgado A, López-Guillermo A, Campo E, Moschetta A, Guarini A, Pileri SA, Ciavarella S.
    Hematol Oncol. 2022 Dec;40(5):864-875. doi: 10.1002/hon.3050. Epub 2022 Aug 9. PMID: 35850118; PMCID: PMC10087298.
  11. OncoPan®: An NGS-Based Screening Methodology to Identify Molecular Markers for Therapy and Risk Assessment in Pancreatic Ductal Adenocarcinoma.
    Tibiletti MG, Carnevali I, Pensotti V, Chiaravalli AM, Facchi S, Volorio S, Mariette F, Mariani P, Fortuzzi S, Pierotti MA, Sessa F.
    Biomedicines. 2022 May 23;10(5):1208. doi: 10.3390/biomedicines10051208. PMID: 35625944; PMCID: PMC9138989
  12. Mixed Neuroendocrine/Non-neuroendocrine Neoplasm (MiNEN) of the Ovary Arising from Endometriosis: Molecular Pathology Analysis in Support of a Pathogenetic Paradigm.
    Maragliano R, Libera L, Carnevali I, Pensotti V, De Vecchi G, Testa M, Amaglio C, Leoni E, Formenti G, Sessa F, Furlan D, Uccella S.
    Endocr Pathol. 2022 Sep;33(3):400-410. doi: 10.1007/s12022-021-09689-8. Epub 2021 Aug 3. PMID: 34342838; PMCID: PMC9420090.
  1. Opti-nQL: An Optimized, Versatile and Sensitive Nano-LC Method for MS-Based Lipidomics Analysis
    Cattaneo A, Martano G, Restuccia U, Tronci L, Bianchi M, Bachi A, Matafora
    Metabolites -- 2021 Oct 21;11(11):720. doi: 10.3390/metabo11110720. This work proposes a sensitive and reproducible LC method for lipidomics analysis, called Opti-nQL (nanoLC-optimized quantitative lipidomics), which can be used for the analysis of a variety of biological systems. Opti-nQL was validated by analyzing cellular lipid extracts of human and murine origin obtained by different lipid extraction methods. 700+ lipid species comprising 16 lipid subclasses were identified, while 400 lipids were identified by MS/MS analysis. The results shown were obtained from the analysis of 40ng proteins, making this method suitable even for the analysis of low abundant samples. Analysis by mass spectrometry thus showed that this method allow more lipids to be identified, as demonstrated by injecting 20 times less material than conventional chromatographic analysis by microflow, making this lipidomic analysis much more reproducible, accurate and robust.
  2. Endosomal trafficking and DNA damage checkpoint kinases dictate survival to replication stress by regulating amino acid uptake and protein synthesis.
    Ajazi A, Bruhn C, Shubassi G, Lucca C, Ferrari E, Cattaneo A, Bachi A, Manfrini N, Biffo S, Martini E, Minucci S, Vernieri C, Foiani M
    Dev Cell. 2021 Sep 27;56(18):2607-2622.e6. doi: 10.1016/j.devcel.2021.08.019. Epub 2021 Sep 16. PMID: 34534458 The influence of Atg6 on replicative stress has been studied by different analytical approaches such as: genetics, genomics, metabolomics, and proteomics. We performed Label Free proteomic analysis of ymr1Δ inp53Δ cells treated with culture medium (YPD) with different aromatic amino acid content (+/- Tryptophan) with the aim of looking for which proteins were altered by aromatic amino acid imbalance and replicative stress. It was observed that the addition of tryptophan to the culture medium of ymr1Δ inp53Δ cells caused obvious changes in the cell proteome.
  3. Human iPSC-based neurodevelopmental models of globoid cell leukodystrophy uncover patient- and cell type-specific disease phenotypes.
    Mangiameli E, Cecchele A, Morena F, Sanvito F, Matafora V, Cattaneo A, Della Volpe L, Gnani D, Paulis M, Susani L, Martino S, Di Micco R, Bachi A, Gritti A
    Stem Cell Reports. 2021 Jun 8;16(6):1478-1495. doi: 10.1016/j.stemcr.2021.04.011. Epub 2021 May 13. PMID: 33989519 Globoid cell leukodystrophy (GLD) is a neurogenerative lysosomal storage disease caused by hereditary β-galactocerebrosidase (GALC) deficiency. This work created patient-specific iPSC cell lines with GLD, used as a human model to study the pathogenesis of GLS and to test the efficacy of gene therapy in relevant neural cell types. GLD neural progeny showed progressive psychosin accumulation, oligodendroglial and neuronal defects, and altered lipid composition. We performed a comprehensive lipidomics analysis using the Opti-nQL method developed in our laboratory (doi: 10.3390/metabo11110720.PMID: 34822378) with the aim of studying the effect of the absence of GALC or its increased expression on the lipidome of iPSCs cells and neural progeny.
  4. PA28-20S proteasome is a proteolytic complex committed to degrade unfolded proteins.
    Frayssinhes JA, Cerruti F, Laulin J, Cattaneo A, Bachi A, Apcher S, Coux O, Cascio P.
    Cell Mol Life Sci. 2021 Dec 16. doi: 10.1007/s00018-021-04045-9. PMID: 34913092 Online ahead of print. PA28 is a nuclear activator of the 20S proteosome that stimulates the hydrolysis of numerous substrates through an ATP- and ubiquitin-independent mechanism. We performed quantitative proteomics analysis by mass spectrometry of products generated by proteosomal degradation by 20S of IGF-1 and MBP proteins. We have shown that PA28 decreases the variability of peptides that are potentially suitable for MHC class I antigen presentation.
  5. MITO-Luc/GFP zebrafish model to assess spatial and temporal evolution of cell proliferation in vivo.
    Latouliere L, Manni I, Ferrari L, Pisati F, Totaro MG, Gurtner A, Marra E, Pacello L, Pozzoli O, Aurisicchio L, Capogrossi MC, Deflorian G, Piaggio G.
    Sci Rep. 2021 Jan 12;11(1):671. doi: 10.1038/s41598-020-79530-5.
  6. Tuning gut microbiota through a probiotic blend in gemcitabine-treated pancreatic cancer xenografted mice.
    Panebianco C, Pisati F, Ulaszewska M, Andolfo A, Villani A, Federici F, Laura M, Rizzi E, Potenza A, Latiano TP, Perri F, Tripodo C, Pazienza V.
    Clin Transl Med. 2021 Nov;11(11): e580. doi: 10.1002/ctm2.580.
  7. Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ.
    Della Chiara G, Gervasoni F, Fakiola M, Godano C, D'Oria C, Azzolin L, Bonnal RJP, Moreni G, Drufuca L, Rossetti G, Ranzani V, Bason R, De Simone M, Panariello F, Ferrari I, Fabbris T, Zanconato F, Forcato M, Romano O, Caroli J, Gruarin P, Sarnicola ML, Cordenonsi M, Bardelli A, Zucchini N, Ceretti AP, Mariani NM, Cassingena A, Sartore-Bianchi A, Testa G, Gianotti L, Opocher E, Pisati F, Tripodo C, Macino G, Siena S, Bicciato S, Piccolo S, Pagani
    Nat Commun. 2021 Apr 20;12(1):2340. doi: 10.1038/s41467-021-22544-y.
  8. Towards population-based genetic screenings for breast and ovarian cancer: A comprehensive review from economic evaluations to patient perspectives
    Ficarazzi F, Vecchi M, Ferrari M, Pierotti M.A.
    Breast 2021 Aug; 58:121-129. doi: 10.1016/j.breast.2021.04.011. Epub 2021 May 12.
  9. Analysis of Italian BRCA1/2 Pathogenic Variants Identifies a Private Spectrum in the Population from the Bergamo Province in Northern Italy.
    Figlioli G, De Nicolo A, Catucci I, Manoukian S, Peissel B, Azzollini J, Beltrami B, Bonanni B, Calvello M, Bondavalli D, Pasini B, Vignolo Lutati F, Ogliara P, Zuradelli M, Pensotti V, De Vecchi G, Volorio S, Verderio P, Pizzamiglio S, Matullo G, Aneli S, Birolo G, Zanardi F, Tondini C, Zambelli A, Livraghi L, Franchi M, Radice P, Peterlongo P.
    Cancers (Basel) 2021 Jan 30;13(3):532. doi:10.3390/cancers13030532. PMID: 33573335
  10. Definition and management of colorectal polyposis not associated with APC/MUTYH germline pathogenic variants: AIFEG consensus statement
    Urso EDL, Ponz de Leon M, Vitellaro M, Piozzi GN, Bao QR, Martayan A, Remo A, Stigliano V, Oliani C, Lucci Cordisco E, Pucciarelli S, Ranzani GN, Viel A, AIFEG group*. * Pensotti V. and De Vecchi G. (AIFEG members at the time of publication).
    Dig Liver Dis 2021 Apr;53(4): 409-417.doi: 10.1016/j.dld.2020.11.018. PMID: 33504457
  11. Mixed Neuroendocrine/Non-neuroendocrine Neoplasm (MiNEN) of the Ovary Arising from Endometriosis: Molecular Pathology Analysis in Support of a Pathogenetic Paradigm.
    Maragliano R, Libera L, Carnevali I, Pensotti V, De Vecchi G, Testa M, Amaglio C, Leoni E, Formenti G, Sessa F, Furlan D, Uccella S.
    Endocr Pathol 2021 Aug 3. doi: 10.1007/s12022-021-09689-8. Online ahead of print. PMID: 34342838
  12. Clinical heterogeneity and reduced penetrance in DICER1 syndrome: a report of three families.
    Azzollini J, Ferrari A, Stracuzzi A, Chiaravalli S, Terenziani M, Spreafico F, Grasso M, Collini P, Pensotti V, Massimino M, Arbustini E, Manoukian S.
    Tumors 2021 Dec;107(6):NP144-NP148. doi: 10.1177/03008916211058788. PMID: 34761719
  13. A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis
    Pradella D, Deflorian G, Pezzotta A, Di Matteo A, Belloni E, Campolungo D, Paradisi, BugattiM,Vermi W, Campioni M, Chiapparino A, Scietti L, Forneris F, Giampietro C, Volf N, Rehman M, Zacchigna S, Paronetto MP, Pistocchi A, Eichmann A, Mehlen P, Ghigna C
    Nat Commun. 2021 Aug 11;12(1):4872. doi: 10.1038/s41467-021-24998-6.
  14. TAp63 regulates bone remodeling by modulating the expression of TNFRSF11B/Osteoprotegerin
    Lena AM, Foffi E, Agostini M, Mancini M, Annicchiarico-Petruzzelli M, Aberdam D, Velletri T, Shi Y, Melino G, Wang Y, Candi E
    Cell Cycle 2021 Nov;20(22):2428-2441. doi: 10.1080/15384101.2021.1985772. Epub 2021 Nov 11.
  15. Exploring the association with disease recurrence of miRNAs predictive of colorectal cancer
    Zanutto S, Ciniselli CM, Belfiore A, Dall'Olio V, Tizzoni L, Varinelli L, Pierotti MA, Battaglia L, Verderio P, Guaglio M, Gariboldi M.
    Int J Biol Markers. 2021 Dec 21:17246008211064915. doi: 10.1177/17246008211064915. Online ahead of print.
  1. Mapping the native interaction surfaces of PREP1 with PBX1 by cross-linking mass-spectrometry and mutagenesis."
    Bruckmann C, Tamburri S, De Lorenzi V, Doti N, Monti A, Mathiasen L, Cattaneo A, Ruvo M, Bachi A, Blasi F.
    Sci Rep. 2020 Oct 8;10(1):16809. doi: 10.1038/s41598-020-74032-w.
  2. "Amyloid aggregates accumulate in melanoma metastasis modulating YAP activity."
    Matafora V, Farris F, Restuccia U, Tamburri S, Martano G, Bernardelli C, Sofia A, Pisati F, Casagrande F, Lazzari L, Marsoni S, Bonoldi E, Bachi A.
    EMBO Rep. 2020 Sep 3;21(9):e50446. doi: 10.15252/embr.202050446.
  3. "Selenoprotein N is an endoplasmic reticulum calcium sensor that links luminal calcium levels to a redox activity".
    Chernorudskiy A, Varone E, Colombo SF, Fumagalli S, Cagnotto A, Cattaneo A, Briens M, Baltzinger M, Kuhn L, Bachi A, Berardi A, Salmona M, Musco G, Borgese N, Lescure A, Zito E.
    Proc Natl Acad Sci U S A. 2020 Sep 1;117(35):21288-21298. doi: 10.1073/pnas.2003847117. Epub 2020 Aug 17.
  4. "IRSp53 controls plasma membrane shape and polarized transport at the nascent lumen in epithelial tubules."
    Bisi S, Marchesi S, Rizvi A, Carra D, Beznoussenko GV, Ferrara I, Deflorian G, Mironov A, Bertalot G, Pisati F, Oldani A, Cattaneo A, Saberamoli G, Pece S, Viale G, Bachi A, Tripodo C, Scita G, Disanza A.
    Nat Commun. 2020 Jul 14;11(1):3516. doi: 10.1038/s41467-020-17091-x.
  5. "ATR expands embryonic stem cell fate potential in response to replication stress."
    Atashpaz S, Samadi Shams S, Gonzalez JM, Sebestyén E, Arghavanifard N, Gnocchi A, Albers E, Minardi S, Faga G, Soffientini P, Allievi E, Cancila V, Bachi A, Fernández-Capetillo Ó, Tripodo C, Ferrari F, López-Contreras AJ, Costanzo V.
    Elife. 2020 Mar 12;9: e54756. doi: 10.7554/eLife.54756.
  6. "Pre- and Post-Zygotic TP53 De Novo Mutations in SHH-Medulloblastoma."
    Azzollini J, Schiavello E, Buttarelli FR, Clerici CA, Tizzoni L, De Vecchi G, Capra F, Pisati F, Biassoni V, Runza L, Carrabba G, Giangaspero C, Massimino M, Pensotti V, Manoukian S.
    Cancers (Basel). 2020 Sep 3;12(9):2503. doi: 10.3390/cancers12092503.
  7. "HPV nonrelated endocervical adenocarcinoma in hereditary cancer syndromes."
    Carnevali I, Di Lauro E, Pensotti V, Sahnane N, Leoni E, Formenti G, Ghezzi F, Sessa F, Tibiletti MG.
    Tumors. 2020 Dec;106(6):NP67-NP72. doi: 10.1177/0300891620936752. Epub 2020 Jul 8.
  8. "HDAC8: A Promising Therapeutic Target for Acute Myeloid Leukemia."
    Spreafico M, Gruszka AM, Valli D, Mazzola M, Deflorian G, Quintè A, Totaro MG, Battaglia C, Alcalay M, Marozzi A, Pistocchi A.
    Front Cell Dev Biol. 2020 Sep 4;8:844. doi: 10.3389/fcell.2020.00844. eCollection 2020.
  9. "MITO-Luc/GFP zebrafish model to assess spatial and temporal evolution of cell proliferation in vivo"
    de Latouliere L, Manni I, Ferrari L, Pisati F, Totaro MG, Gurtner A, Marra E, Pacello L, Pozzoli O, Aurisicchio L, Capogrossi MC, Deflorian G, Piaggio G.
    Sci Rep. 2021 Jan 12;11(1):671. doi: 10.1038/s41598-020-79530-5. PMID: 33436662; PMCID: PMC7804000.
  10. "JAM-A Acts via C/EBP-α to Promote Claudin-5 Expression and Enhance Endothelial Barrier Function"
    Kakogiannos N, Ferrari L, Giampietro C, Scalise AA, Maderna C, Ravà M, Taddei A, Lampugnani MG, Pisati F, Malinverno M, Martini E, Costa I, Lupia M, Cavallaro U, Beznoussenko GV, Mironov AA, Fernandes B, Rudini N, Dejana E, Giannotta M.
    Circ Res. 2020 Sep 25;127(8):1056-1073. doi:10.1161/CIRCRESAHA.120.316742. Epub 2020 Jul 15.
  11. "Intra-tumour heterogeneity of diffuse large B-cell lymphoma involves the induction of diversified stroma-tumour interface."
    Sangaletti S, Iannelli F, Zanardi F, Cancila V, Portararo P, Botti L, Vacca D, Chiodoni C, Di Napoli A, Valenti C, Rizzello C, Vegliante MC, Pisati F, Gulino A, Ponzoni M, Colombo MP, Tripodo C.
    EBioMedicine. 2020 Nov; 61:103055. doi: 10.1016/j.ebiom.2020.103055. Epub 2020 Oct 20.
  12. "Plasma miRNA-based signatures in CRC screening programs."
    Zanutto S, Ciniselli CM, Belfiore A, Lecchi M, Masci E, Delconte G, Primignani M, Tosetti G, Dal Fante M, Fazzini L, Airoldi A, Vangeli M, Turpini F, Rubis Passoni GG, Viaggi P, Arena M, Motta RIO, Cantù AM, Crosta C, De Roberto G, Iannuzzi F, Cassinotti A, Dall'Olio V, Tizzoni L, Sozzi G, Meroni E, Bisanti L, Pierotti MA, Verderio P, Gariboldi M.
    Int J Cancer. 2020 Feb 15;146(4):1164-1173. doi: 10.1002/ijc.32573. Epub 2019 Aug 5. PMID: 31304978 (*)
  13. "A self-sustaining endocytic-based loop promotes breast cancer plasticity leading to aggressiveness and pro-metastatic behavior."
    Schiano Lomoriello I, Giangreco G, Iavarone C, Tordonato C, Caldieri G, Serio G, Confalonieri S, Freddi S, Bianchi F, Pirroni S, Bertalot G, Viale G, Disalvatore D, Tosoni D, Malabarba MG, Disanza A, Scita G, Pece S, Pilcher BK, Vecchi M, Sigismund S, Di Fiore PP.
    Nat Commun. 2020 Jun 15;11(1):3020. doi: 10.1038/s41467-020-16836-y. PMID: 32541686
  14. "Low-Dose Aspirin in High-Risk Individuals With Screen-Detected Subsolid Lung Nodules: A Randomized Phase II Trial."
    Bonanni B, Serrano D, Maisonneuve P, Veronesi G, Johansson H, Aristarco V, Varricchio C, Cazzaniga M, Lazzeroni M, Rampinelli C, Bellomi M, Vecchi M, Spaggiari L, Vornik L, Brown PH, Beavers T, Guerrierri-Gonzaga A, Szabo E.
    JNCI Cancer Spectr. 2020 Oct 20;4(6): pkaa096. doi: 10.1093/jncics/pkaa096. eCollection 2020 Dec.
  15. Graphene-Based Strategies in Liquid Biopsy and in Viral Diseases Diagnosis
    Annalaura Cordaro, Giulia Neri, Maria Teresa Sciortino, Angela Scala, Anna Piperno
    Nanomaterials (Basel) 2020 May 26;10(6):1014 | PMID: 32466536, PMCID: PMC7353367, DOI: 10.3390/nano10061014
  16. Single cell-derived spheroids capture the self-renewing subpopulations of metastatic ovarian cancer
    Velletri T, Villa CE, Cilli D, Barzaghi B, Lo Riso P, Lupia M, Luongo R, López-Tobón A, De Simone M, Bonnal RJP, Marelli L, Piccolo S, Colombo N, Pagani M, Cavallaro U, Minucci S, Testa G.
    Cell Death Differ. 2022 Mar;29(3):614-626. doi: 10.1038/s41418-021-00878-w. Epub 2021 Nov 29. PMID: 32694652
  17. Direct cleavage of caspase-8 by herpes simplex virus 1 tegument protein US11.
    Musarra-Pizzo M, Pennisi R, Lombardo D, Velletri T, Sciortino MT.
    Sci Rep. 2022 Jul 19;12(1):12317. doi: 10.1038/s41598-022-15942-9. PMID: 35853963
  18. (*) "Plasma miRNA-based signatures in CRC screening programs."
    Gariboldi M et al: reported among the most significant papers of the year at World Cancer Day 2020.
  1. Towards a population screening for breast/ovarian cancer genetic risk?
    Marco A. Pierotti, Filomena Ficarazzi.
    OECI Magazine, No. 1, Year 4, May 2020. Organization of European Cancer Institutes (OECI).
  2. Guideline on BRCA1 and BRCA2 gene analysis in clinical settings: test access criteria, update on diagnostic platforms, and somatic test interpretation
    Italian Society of Human Genetics - Italian Society of Human Genetics.
    Edited by: SIGU*- Oncology Genetics GdL, Molecular Genetics GdL, Pharmacogenomics GdL
    Coordinators: Daniela Turchetti, Enrico Tagliafico, Emilio Di Maria
    Extenders: Davide Bondavalli, Ileana Carnevali, Arcangela De Nicolo, Emilio Di Maria, Marco Montagna, Lidia Moserle, Valeria Pensotti, Enrico Tagliafico, Maria Grazia Tibiletti, Silvia Tognazzo, Daniela Turchetti, Liliana Varesco.
    Editorial team: Francesca Ariani, Linda Battistuzzi, Loris Bernard, Benedetta Bertonazzi, Francesca Boaretto, Bernardo Bonanni, Davide Bondavalli, Adelaide Caligo, Daniele Calistri, Mariarosaria Calvello, Paola Carrera, Rossella Caselli, Angelo Cellamare, Fabiana Crò, Francesca Crosti, Arcangela De Nicolo, Giovanna De Vecchi, Emilio Di Maria, Irene Feroce, Simona Ferrari, Maurizio Genuardi, Daniela Giachino, Viviana Gismondi, Lea Godino, Milena Gusella, Cristiana Lo Nigro, Emanuela Lucci Cordisco, Isabella Mammi, Siranoush Manoukian, Eleonora Marchina, Maria Antonietta Mencarelli, Piergiorgio Modena, Marco Montagna, Lidia Moserle, Alfredo Orrico, Sandro Orrù, Valeria Pensotti, Maria Piane, Paolo Radice, Carla Ripamonti, Daniela Rivera, Enrico Tagliafico, Maria Grazia Tibiletti, Rossella Tita, Silvia Tognazzo, Daniela Turchetti, Vera Uliana, Liliana Varesco, Daniela Zuccarello.
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